Impact (REF3a/b)

Impact template (REF3a)

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All impact case studies

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Individual case studies

A: The GRACE risk score: a reference standard for the management of acute coronary syndrome (62K)

B: Avoiding ineffective statin use in aortic stenosis (45K)

C: Detailed analysis of trial of lapatinib in combination with capecitabine in advanced, HER2+ breast cancer leads to marketing authorisation worldwide (55K)

D: Preventing deaths from pesticide self-poisoning in rural Asia – pralidoxime is hazardous and banning organophosphorus insecticides is beneficial (49K)

E: Uterine artery embolisation is superior to surgery in the short term, for the treatment of symptomatic uterine fibroids (48K)

F: By defining the minimum liver remnant required, volumetric analysis is now the pre-operative standard of care in liver cancer surgery worldwide (64K)

G: Diagnosis from gene discovery – developmental disorders of eye, brain, nerve and skeleton (66K)

H: Ovarian cryopreservation can restore fertility in women following cancer treatment that would otherwise irreversibly deny them children (63K)

I: Reducing blood transfusions in intensive care and surgery saves precious blood, reduces costs and decreases patient risk (54K)

J: Elective delivery of pregnant women reduces perinatal mortality, particularly in mothers over 40 years of age (45K)

K: Progesterone does not prevent preterm birth in twin pregnancy (STOPPIT study) (44K)

L: Pharmacological and interventional therapies for acute coronary syndromes improve patient outcome (81K)

M: Defining patient needs and delivering evidence-based palliative and end-of-life care for non-malignant disease, through services that can be delivered in developed and low-income countries (64K)

N: Detailed epidemiological studies of people with allergy have triggered policy developments and catalysed service innovations to enhance care (70K)

O: Making technological advancement safer by defining the specific attributes of carbon nanofibres that are detrimental to human health (55K)

P: Testicular Dysgenesis Syndrome is linked to endocrine-disrupting phthalate exposure; specific phthalates are now banned from children’s mouth toys (54K)

Q: Accurate epidemiological pneumonia incidence and mortality estimates have influenced child health policy to reduce global child pneumonia mortality (75K)

R: Community-directed delivery of doxycycline in Cameroon demonstrates effectiveness as a treatment for onchocerciasis (river blindness) in Africa that avoids adverse effects associated with ivermectin (44K)

S: Progesterone receptor modulators are effective in emergency contraception and therapy of heavy menstrual bleeding/fibroids (62K)

T: Commercialisation of ScreenTape™ - a microfluidic tool for genomics, next-generation sequencing and proteomic analysis (371K)

U: Invention, licensing and commercialisation of optical projection tomography microscopy (87K)

V: Dolly the sheep - the first cloned mammal and a public icon for regenerative medicine (243K)