Output details
15 - General Engineering
University of Surrey
Article title
A mathematical model of brain tumour response to radiotherapy and chemotherapy considering radiobiological aspects
Type
D - Journal article
Title of journal
Journal of Theoretical Biology
Article number
-
Volume number
262
Issue number
3
First page of article
553
ISSN of journal
00225193
Year of publication
2010
URL
-
Number of additional authors
-
Additional information
Temozolomide (TMZ) has produced the largest single improvement in the outcome for brain cancer in 50 years, although the mechanism is not well understood. This paper shows that the effect of TMZ chemotherapy can be included in our brain cancer model. We show that TMZ appears to act as a radio-sensitizer and is not an independently cytotoxic agent. We also separate the effects of single and double strand DNA breaks in the model and show that the main effect of TMZ is on the repair of single strand breaks. This paper will accelerate the widespread use of combined TMZ and radiotherapy.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
