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Hemodynamics and In-stent Restenosis: Micro-CT Images, Histology, and Computer Simulations

Restenosis is a serious complication of coronary artery stenting. Whilst many papers describe the analysis of flow in stented arteries, these consider idealised geometries with symetrically-deployed stents. Data was obtained from pig experiments and a model of the deployed 3D geometry was reconstructed from micro-CT. The vessel wall reaction was determined from histological sections. Direct comparison of hemodynamic parameters and biological response supports the hypothesis that low and oscillatory WSS give an increased neointimal response. The realistic geometry gives to a markedly non-uniform distribution of WSS. The correlation with asymmetric growth cannot be appreciated in idealized geometries.