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Global gene expression analysis of human erythroid progenitors

Understanding patterns of gene expression during erythropoiesis is crucial for synthesizing erythroid developmental biology. Rigorous and original data analysis of microarray gene expression data made many important discoveries, including the nature of twelve genes in maturing human primary erythroblasts and potential transcription factors regulating gene expression during terminal erythropoiesis. Future developments of this study, funded by National Institute of Health Research (NIHR RP-PG-0310-1004), are expected to lead to better management of blood disorders in humans. Published in a very high impact factor journal, this significant work received a Presidential Prize at the British Society for Haematology meeting in 2011.