Output details
13 - Electrical and Electronic Engineering, Metallurgy and Materials
University of Sheffield : B - Materials Science and Engineering
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Article title
Hyperbranched poly(NIPAM) polymers modified with antibiotics for the reduction of bacterial burden in infected human tissue engineered skin
Type
D - Journal article
Title of journal
Biomaterials
Article number
-
Volume number
32
Issue number
1
First page of article
258
ISSN of journal
01429612
Year of publication
2011
Number of additional authors
5
Additional information
We developed hyperbranched poly (NIPAM) polymers functionalised with antibiotics sensitive to the presence of bacteria. We applied these novel polymers to our tissue engineered human skin model of an infected burn wound. When the polymers were removed from the infected skin, they bound bacteria, significantly reducing the bacterial load in the infected skin model. This approach to reducing bacterial contamination of wounds has now attracted TSB funding led by Smith & Nephew (£350k) to make an impact in the management of chronic wounds in man.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-