Output details
15 - General Engineering
University of Leeds
Article title
An Alternative Method to Isolate Pharmaceutical Intermediates
Type
D - Journal article
Title of journal
Organic Process Research & Development
Article number
-
Volume number
15
Issue number
1
First page of article
84
ISSN of journal
1083-6160
Year of publication
2010
URL
-
Number of additional authors
1
Additional information
We report the invention of Solid Supported Evaporation (SSE) a new technology to isolate pharmaceutical intermediates in an inherently safe way avoiding both crystallisation and distillation. This resolves a significant problem in the development of new pharmaceutical entities: i.e. the first isolation of new chemical species. SSE gives a free flowing powder whilst requiring very little development and replaces total evaporation of the solvent which carries an inherent high risk of explosion. SSE has been applied in AstraZeneca at 20L scale and work in KTH (Brian.Whitlock@astrazeneca.com, Ake.Rasmuson@ul.ie) confirmed the invention’s generic nature.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
