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12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering

University of Cambridge

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Output 39 of 110 in the submission

Article title

Extrusion-spheronisation of microcrystalline cellulose pastes using a non-aqueous liquid binder.

Type

D - Journal article

DOI

10.1016/j.ijpharm.2009.12.058

Title of journal

Int J Pharm

Article number

Volume number

389

Issue number

1-2

First page of article

ISSN of journal

1873-3476

Year of publication

2010

URL

Number of additional authors

Additional information

Extrusion-spheronisation is a popular pharmaceutical granulation technique but encounters problems when the active ingredient is incompatible with water. This study demonstrated that non-aqueous liquid binder selection can be guided by biopolymer chemistry. The group’s leading work on the mechanics of extrusion-spheronisation resulted in a plenary lecture on the topic at the European PharmSci Fair in Prague, 2011. The work was supported by MSD (contact Dr Christian Seiler, email available) and the company funded a follow-on Dorothy Hodgkin PhD studentship in this area. Author Mascia moved on to the MIT/Novartis institute to a key role in developing continuous pharmaceutical granulation.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract