Output details
15 - General Engineering
Queen Mary University of London
Article title
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response.
Type
D - Journal article
Title of journal
Cell Mol Life Sci
Article number
-
Volume number
69
Issue number
17
First page of article
2967
ISSN of journal
1420-9071
Year of publication
2012
URL
-
Number of additional authors
1
Additional information
This study is the first to show that the structure of primary cilia is regulated by inflammatory cytokines and that this drives the inflammatory process. As such the paper highlights a totally novel role for primary cilia in mediating inflammation in cartilage and a variety of other cell types. Hence these findings open the door to a potential new therapeutic target for drugs aimed at controlling inflammation. The work was widely picked up by the scientific press and formed the preliminary data which led to over £800k grant funding from the MRC, Arthritis Research UK and the AO Foundation.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
