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15 - General Engineering

Brunel University London

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Output 142 of 258 in the submission

Article title

Intermittent counter-current extraction—Effect of the key operating parameters on selectivity and throughput

Type

D - Journal article

DOI

10.1016/j.chroma.2011.03.072

Title of journal

Journal of Chromatography A

Article number

Volume number

1218

Issue number

First page of article

6072

ISSN of journal

00219673

Year of publication

2011

URL

http://www.sciencedirect.com/science/article/pii/S0021967311004511/pdfft?md5=fefc41d460817a30114158eb7a483c8c&pid=1-s2.0-S0021967311004511-main.pdf

Number of additional authors

Additional information

Intermittent Counter-current Extraction (ICcE), a novel liquid-liquid extraction process, was demonstrated for the first time resulting in continuous processing using counter-current chromatography instruments being a key part of the TSB High Value Manufacturing research programme on “Scalable Technology for the Extraction of Pharmaceuticals” Grant No. TP14/HVM/6/I/BD506K. One major outcome of this grant was a 1.6X reduction in solvent usage and therefore reduced cost when using ICcE for the clean-up of a pharmaceutical API waste streams compared to conventional chromatography. This latter research won the poster prize at the Symposium on Preparative and Industrial Chromatography and Allied Techniques SPICA2012.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract