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13 - Electrical and Electronic Engineering, Metallurgy and Materials

University of Leeds

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Output 8 of 64 in the submission

Article title

Applying broadband terahertz time-domain spectroscopy to the analysis of crystalline proteins: a dehydration study

Type

D - Journal article

DOI

10.1107/S0021889810043372

Title of journal

Journal of Applied Crystallography

Article number

Volume number

Issue number

First page of article

129

ISSN of journal

0021-8898

Year of publication

2010

URL

Number of additional authors

Additional information

ADB-1: This paper, with the Astbury Centre for Structural Molecular Biology, reports the first measurements of functional, single crystal proteins using broadband terahertz time-domain spectroscopy, and quantifies the effect of protein hydration on the terahertz signal. This work underpins terahertz frequency studies, under physiological conditions, of protein dynamics, potentially allowing them to be related to protein structure and function. Supported by the Leverhulme Trust, this contributed to an EPSRC postdoctoral fellowship (EP/I026657, Burnett, £382,793), a BBSRC partnering award (BB/I025247, PI:Pearson, £51,273) with the Hauptman-Woodward Medical Research Institute (esnell@hwi.buffalo.edu), and a 2013 US Defense Threat Reduction Agency award (HDTRA1-14-C-0013, PI:Linfield, $255,671).

Interdisciplinary

Yes

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract