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The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes.

Glaucoma is a leading cause of blindness affecting 65 million worldwide; the only treatment is to lower intraocular pressure (IOP). This paper explains how drugs that inhibit rho kinase more successfully lower IOP by suppressing cellular contractility/intracellular connectivity. Data from this paper were presented at 3 talks at international conferences and in a “special issue” invited review article (Exp Eye Research 2009) . The paper provided data for a multi-institutional 5-year grant from the US NIH (£333k to Overby as co-PI; EY019696) and a 2-yr US-based charity grant (BrightFocus Foundation, £60k; G2009-032) to study the cell mechanical basis for glaucoma.