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12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering

University of Cambridge

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Article title

Biopolymer mediated trehalose uptake for enhanced erythrocyte cryosurvival

Type

D - Journal article

DOI

10.1016/j.biomaterials.2010.04.020

Title of journal

BIOMATERIALS

Article number

Volume number

Issue number

First page of article

6096

ISSN of journal

0142-9612

Year of publication

2010

URL

Number of additional authors

Additional information

This study, funded by a contract with Pfizer Inc (now Zoetis Inc, cf. Dr Paul Domionowski, contact available on request) employed a synthetic biopolymer to increase membrane permeability to the preservative trehalose and so impart cellular osmoprotection and resistance to freezing. The results were filed for IP protection (UK Patent Application No. 1000999.1) and underpin a BBSRC BRIC award (BB/I016961/1). A research collaboration with GSK is being concluded (cf. Dr Christina Basford: contact available on request) to test the preservation technology with their cell line.

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract