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Expanding 3D geometry for enhanced on-chip microbubble production and single step formation of liposome modified microbubbles

JRM-1: This paper reports the development of microfluidic systems, which provide a one-chip solution for the creation of microbubbles with chemotherapy payloads/antibodies targeting colorectal cancer. The production rate of microbubbles is dramatically increased to clinically relevant levels, and their efficacy is being evaluated by the Leeds Institute of Biomedical and Clinical Sciences in pre-clinical mice models, supported by EPSRC (EP/I000623; PI:Evans; £1.2M). The research contributed to the award of McLaughlan’s 2013 Leverhulme Early Career Fellowship (ECF-2013-147), whilst the potential use of ultrasonics in robotic surgical tools supported the £4.3M EPSRC National Facility for Innovative Robotic Systems awarded to Leeds (2013).