Output details
11 - Computer Science and Informatics
University of Exeter
Article title
Robustness from flexibility in the fungal circadian clock
Type
D - Journal article
Title of journal
BMC Systems Biology
Article number
-
Volume number
4
Issue number
1
First page of article
88
ISSN of journal
1752-0509
Year of publication
2010
URL
-
Number of additional authors
3
Additional information
<28> This article appeared in one of the principal computational systems biology journals, and also featured in the Faculty of 1000 Biology, Most Viewed Top 10 and Hidden Jewels Top 10 in Genomics and Genetics in July 2010. It introduces a new predictive model of a paradigm circadian network constructed through optimisation to multiple experimental data sets. The model is used as to show that multiple interlocked feedback loops can give rise to circuits in which evolutionary flexibility can promote robustness, suggesting a more general design principle. The work was a key component in an EPSRC-funded interdisciplinary project (£500k).
Interdisciplinary
-
Cross-referral requested
-
Research group
1 - Artificial Intelligence
Citation count
15
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
