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Self-Optimizing Continuous Reactions in Supercritical Carbon Dioxide

The system described in this paper demonstrates a self-optimising continuous flow reactor system. In effect, the reactor and its process control instrumentation become an autonomous unit into which the reactants are pumped, and from which products emerge with optimized yield without requiring any intervention from the operator. These systems are capable of complete optimisation of a laboratory synthesis within a working day and have been extended to optimise numerous reaction outputs such as yield, E factor, space time yield. This work has led to a collaborative project at the University of Leeds with AstraZeneca evaluating methodologies for process optimisation.