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Prediction of attrition in agitated particle beds

After a failure in large scale manufacturing of a new drug due to excessive attrition during filter drying, Dr RD Dennehy, GSK, approached us with a request to develop a predictive methodology for attrition propensity of organic crystals using a small quantity of materials available at the early development stage. In this paper we have analysed the prevailing shear stresses due to bed agitation using cutting edge numerical simulation tools, validated by Positron Emision Particle Tracking and have devised a method, whereby the experimentally-determined particle breakage rate is incorportaed in the numerical simulations, enabling excellent predictability from a fundamental base.