Output details

Online characterisation of nanoparticle suspensions using dynamic light scattering, ultrasound spectroscopy and process tomography

Nanoparticle processing faces major challenges in process scale-up and maintaining consistency and reproducibility in product quality. Online process analytical technology for real-time characterisation of product quality and process conditions is studied as the potential enabling technology to address the challenges. An on-line dynamic light scattering spectrometer was designed, probably the first on-line system in the world, and integrated with ultrasound spectroscopy and electrical resistance tomography for characterisation of nanoparticle suspensions in particle size distribution, zeta potential, conductivity and solid concentration and mixing behaviour. Key future research directions were identified and useful knowledge learnt providing useful information for nanoparticle manufacturing.