Output details

First implantable device for hypoxia-mediated angiogenic induction.

This is the culmination of five years work leading to a granted patent. This reports using 3D tissue models to produce core cell hypoxia resulting in a full angiogenic factor cascade. This cascade from, an expendable cell depot, stimulated host vessel ingrowth/ re-vascularisation from around the implanted material. This is a collaboration with tissue engineers in China and we show in a preclinical animal study, that angiogenesis was substantially accelerated. This is the first practical hypoxia stimulated angio-therapy (using a physiological, whole-system approach), opening the way for wider clinical development of hypoxia tissue engineered constructs stimulating angiogenesis.