Output details

Injectable system for spatio-temporally controlled delivery of hypoxia-induced angiogenic signalling.

We trapped hypoxia-induced signalling produced angiogenic factors of human dermal fibroblasts into collagen depots. Cell-produced angiogenic factors (e.g. VEGF, FGF, PLGF, IL-8) were trapped within the nano-porous matrix of the acellular compartment as they diffused through it. These were stored then re-dissolved to be utilised in an injectable system to induce vascularisation in grafts. This provides induction of spatio-temporally controlled angiogenesis and has implications for aiding graft incorporation during surgical transplantation and would substantially reduce graft rejection in humans. The author made a substantial contribution to the conception, design and to carrying out the study (including acquisition of study data).