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Effect of increased strut porosity of calcium phosphate bone graft substitute biomaterials on osteoinduction.

This work showed that increasing the number of micro-pores with a silicate-substituted hydroxyapatite graft material resulted in a significant 5-fold increase in the induction of bone formation (osteoinduction) within the scaffold when placed in an ectopic site. This is of high importance as it led to the development of the product 'Inductigraft' which is now used clinically and marketed by Baxter Healthcare. This increase in osteoinduction may have a significant effect in augmenting bone formation in bony repair sites in patients, especially the elderly patient group, where the regeneration of good quality bone can often be unpredictable.