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Increase in cerebral aerobic metabolism by normobaric hyperoxia after traumatic brain injury.

We have developed the first non invasive assessment of cerebral cellular oxygen metabolism in brain injured patients during normobaric hyperoxia. The results demonstrate that an approach as simple as enriched O2 therapy can alter brain metabolism in severe traumatic brain injury for which no other established treatment exists, and provides evidence that near infrared spectroscopy measures of cytochrome c oxidase have value as a clinical marker of oxygen metabolism. The findings triggered an editorial suggesting a clinical trial of normobaric hyperoxia in several thousand brain injured patients. I am the lead physics author on this clinical publication.