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Assessment of cerebral venous return by a novel plethysmography method

With >80 subjects, this study was the first clinical trial to conclusively demonstrate that MS patients diagnosed with chronic cerebrospinal venous insufficiency (CCSVI) have profoundly altered cerebral venous drainage characteristics compared with healthy controls. Novel cervical plethysmography, together with a systems engineering approach, was employed to characterize (for the first time) the dynamics of the cerebral venous drainage system – something that would be impossible using Doppler ultrasound. As such, the study represented a major leap forward; clarifying the controversy associated with CCSVI and demonstrating that CCSVI is a real physiological phenomenon, which is associated with MS.