Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Bradford
Article title
Cine cerebrospinal fluid imaging in multiple sclerosis
Type
D - Journal article
Title of journal
Journal of Magnetic Resonance Imaging
Article number
-
Volume number
36
Issue number
4
First page of article
825
ISSN of journal
10531807
Year of publication
2012
URL
-
Number of additional authors
12
Additional information
With >100 subjects, this is the largest clinical trial to investigate cerebrospinal fluid (CSF) dynamics in MS. It demonstrated that MS is associated with increased CSF pulsatility and showed (for the first time) that this is correlated with MS-lesion formation. Beggs used a systems engineering approach to interpret the results. Follow-on work by Beggs (BMC Medicine 2013, 11:142 and Journal of Magnetic Resonance Imaging – in press) has shown that increased CSF pulsatility is probably due to constricted venous outflow altering intracranial compliance. Collectively, this work represents a major leap forward in understanding the CSF dynamics associated with MS.
Interdisciplinary
-
Cross-referral requested
-
Research group
A - Advanced Materials Engineering
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
