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Synthesis of nanoporous aluminosilicate materials and their application as highly selective heterogeneous catalysts for the synthesis of β-amino alcohols

This work, funded by the EPSRC, is the result of a continuing collaborative relationship with the Cardiff Catalysis Institute (Cardiff University). This paper reports the synthesis, characterisation and application of nanoporous aluminosilicate materials as highly flexible and well characterised heterogeneous solid acid catalysts, which efficiently catalyse the regioselective addition of aromatic amines to epoxides to produce beta-amino alcohols in high yields and with excellent selectivity. In contrast to previous reports for the generation of these industrially important compounds, this protocol employs near stoichiometric quantities of reagents which greatly enhances the overall atom efficiency of the transformation.