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Cortical Overgrowth in Fetuses With Isolated Ventriculomegaly

The clinical implementation of a novel method we have previously developed (Jiang, IEEE Trans Med Imaging, 2007), which solves the previously intractable problem of fetal motion and for the first time allowed accurate 3-D volumetric MRI imaging of the fetus in utero. We found that infants with enlarged ventricular cavities do not have, as was previously assumed, reduced brain tissue, but instead increased brain growth. Previously regarded as the result of cerebral atrophy; our findings mean that researchers need to find a cause for excessive brain growth in these infants. This work is published in a major neurology journal.