Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
Newcastle University
Article title
Probing interactions of the HIV protein GP120 with lipids and CD4 receptors
Type
D - Journal article
Title of journal
Soft Matter
Article number
-
Volume number
9
Issue number
10
First page of article
2803
ISSN of journal
1744-6848
Year of publication
2013
Number of additional authors
2
Additional information
This paper determines the self assembly and interactions of proteins and receptors involved in the attachment of the HIV virus particles to cell membranes. By understanding how the viral particle attaches at the molecular level strategies to block attachment can be derived. This paper demonstrates for the first time that part of the viral protein attacks and sinks into the lipids as well as specifically interacts with cell membrane receptors. The work reported in this paper was carried out as part of EPSRC project “Surface Nanostructures For The Study of Biomolecular Recognition, Chirality And Crystal Growth” (EP/F025688/1; £298k).
Interdisciplinary
Yes
Cross-referral requested
-
Research group
A - Advanced Materials
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
