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Effect of Silicate-Substitution on Attachment and Early Development of Human Osteoblast-Like Cells Seeded on Microporous Hydroxyapatite Discs

This paper presented the concept that enhanced bioactivity of silicon-substituted hydroxyapatite synthetic bone graft substitutes (SBGS) is through improved bone cell interaction via control of the protein interlayer ‘quality’ (species and conformation), identifying a mechanism by which SBGS physicochemistry directs cell development down the bone production pathway (basis of Guths PhD, granted). The work won the ESB student poster prize (UK, 2007) and lead to an invited lecture at ICACC (USA, 2010). Work was also key to the award of two PhD studentships (Mafina, EPSRC, granted; Castagna, ApaTech, ongoing) to study competitive protein binding on hydroxyapatite versus silicon-substituted hydroxyapatite surfaces.