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An integrated silicon sensor with microfluidic chip for monitoring potassium and pH

Neural disorders are characterized by interrelated chemical and electrical changes in the brain. To date, only electrical neural activity is monitored using specialised electrodes. This paper examines the merits of a chemical sensor for use in a novel ionic brain monitoring interface. This is a first step towards a new neural monitoring modality to provide simultaneous chemical and electrical measurements during different stages of brain activity providing exciting new insight. The resulting technology is expected to have a vast range of clinical applications for brain disease diagnosis and treatment, including epilepsy and depression.