Output details
15 - General Engineering
University of Surrey
Article title
Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma
Type
D - Journal article
Title of journal
Radiation Oncology
Article number
-
Volume number
8
Issue number
1
First page of article
65
ISSN of journal
1748-717X
Year of publication
2013
URL
-
Number of additional authors
-
Additional information
This paper contains the first in vitro studies combining radiotherapy with two drugs, temozolomide and ABT-888. These drugs target different DNA repair pathways and both are capable of crossing the blood-brain barrier. Temozolomide only works for 45% of the population but its effects are found to be additive to radiation. It shows that in combination the drugs have a radio-sensitising effect on the 55% of the population where temozolomide had little effect. As a result, the combination of these drugs and radiotherapy will soon go into clinical trials.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
