Output details
13 - Electrical and Electronic Engineering, Metallurgy and Materials
University of Southampton
Article title
On-chip epithelial barrier function assays using electrical impedance spectroscopy
Type
D - Journal article
DOI
Title of journal
Lab on a Chip
Article number
-
Volume number
10
Issue number
12
First page of article
1611
ISSN of journal
1473-0197
Year of publication
2010
Number of additional authors
5
Additional information
Significance of output:
This paper describes a microfluidic platform for ex-vivo tissue engineering, where cells harvested from human airways are culture in a micro-chip. The final tissue construct is identical to human lung tissue and enables complex analysis of the effect of allergens, viruses and drugs without human or animal experimentation. This initial work led to a new grant (NC3R G1001598) to further the understanding of the human airways and for research into treatment of allergy and asthma. We are currently in discussion with GSK to develop the technology to investigate and improve aerosol drug delivery into the lung.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
