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Optimal Design of Clinical Tests for the Identification of Physiological Models of Type 1 Diabetes Mellitus

The paper presents a model-based method for personalised medical treatment for Type-1 Diabetes, improving identification of individual subject’s characteristics, their response to glucose and insulin treatment, and the design of optimal identification protocols. Initiated at Imperial, the last author utilised and transferred to Padova methods pioneered by Macchietto, gaining an Assistant Professorship. The first author, based on the work at Imperial, has been offered a position at UCL (v.dua@ucl.ac.uk). The approach’s potential for providing safer, faster, more effective protocols for tailoring diabetes treatment to individual subjects has been highlighted in an authoritative systems-biology review series (DOI=10.1002/wsbm.1204) and biomedical research (DOI=10.1109/tbme.2011.2176939).