Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
Newcastle University
Article title
Characterising single fibronectin-integrin complexes
Type
D - Journal article
Title of journal
Soft Matter
Article number
-
Volume number
8
Issue number
22
First page of article
6151
ISSN of journal
1744-6848
Year of publication
2012
Number of additional authors
2
Additional information
The integrin/fibronectin interaction is responsible for cell adhesion and is fundamental to tissue healing, disease and repair. Integrins are over expressed in cancer cells and provide a target for many of the current and developing chemotherapies. The research described in this paper isolated, for the first time, single molecule complexes of individual integrins and fibronectins, and allowed confirmation that fibronectin binds to the head region of integrins and that the lipid bilayer stabilises such interactions. The paper shows the highest resolution image to date of a single integrin molecule and integrin/fibronectin complex.
Interdisciplinary
Yes
Cross-referral requested
-
Research group
A - Advanced Materials
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
