Output details
13 - Electrical and Electronic Engineering, Metallurgy and Materials
University of Strathclyde
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Article title
A systematic survey of the response of a model NF-κBκB signalling pathway to TNFαTNFα stimulation
Type
D - Journal article
Title of journal
Journal of Theoretical Biology
Article number
-
Volume number
297
Issue number
-
First page of article
137
ISSN of journal
0022-5193
Year of publication
2012
URL
-
Number of additional authors
7
Additional information
This research integrates modelling, systems analysis and experimental techniques to explore oscillatory phenomena in NF-kB signal pathway, which is pivotal in controlling innate immunity, but can also contribute to carcinogenesis. For the first time sustained oscillation in this pathway was investigated using bifurcation theory together with experimental evidence. It brought new insights and inspired a number of further experimental efforts (Prof. White’s lab at Manchester University, mike.white@manchester.ac.uk; Prof. Hoffmann’s lab, University of California, San Diego, ahoffman@ucsd.edu).
Interdisciplinary
-
Cross-referral requested
-
Research group
E - Institute for Energy and Environment (InstEE)
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-