Output details

A microdroplet dilutor for high-throughput screening

Significance of output:

Pipetting and dilution are universal processes used in chemical and biological laboratories to assay and experiment. In microfluidics such operations are equally in demand, but difficult to implement. To this end, we developed a dilution module for high-throughput screening using droplet-based microfluidics. As a proof of concept, we used the dilutor to perform a high-throughput homogeneous DNA-binding assay using only nanolitres of sample.

The paper was selected as cover page by Nature Chemistry and highlight by Glenn M Walker in Nature news and views: ‘Microfluidics: Pensioning off pipettes’. A spin-out company has been set up based on the technologies developed in the paper. Patent pending.