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Output details

15 - General Engineering

Queen Mary University of London

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Article title

2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation

Type

D - Journal article

DOI

10.1126/science.1185988

Title of journal

Science

Article number

Volume number

327

Issue number

5973

First page of article

1653

ISSN of journal

0036-8075

Year of publication

2010

URL

Number of additional authors

Additional information

Here we combined topographical imaging with localized application of agonists via nanopipette and fluorescence resonance energy transfer to uncover the mechanisms leading to the abnormal cAMP compartmentation in heart failure. These findings are of great importance for the development of new strategies for heart failure treatment. The work was featured in Editor’s choice in Science Signaling 3(115), 2010, p93 and Perspective in Science 327(5973), 2010, p1586. The work originated from a project funded by Wellcome Trust (090594/Z/09/Z) and lead to Imperial College Research Excellence Award. The study also helped secure follow-up BHF New Horizons grant (NH/10/3/28574).

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract