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Faster O2 uptake kinetics in canine skeletal muscle in situ after acute creatine kinase inhibition

Using acute pharmacological inhibition of creatine kinase in mammalian muscle in situ, the novel findings of this highly cited article show that creatine kinase provides a locus of control for at least two parameters of aerobic function: oxygen consumption kinetics and contractile efficiency. These data promote the design of new therapeutic interventions to target creatine kinase activity in order to improve muscle and exercise function in patient populations who are compromised by limited capacity for muscle O2 transport or utilization. In recognition of the significance of this finding, the paper was accompanied by an invited ‘Perspectives’ editorial in the journal.