Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Manchester : A - Chemical Engineering
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Article title
A New Dynamic in Mass Spectral Imaging of Single Biological Cells
Type
D - Journal article
Title of journal
Analytical Chemistry
Article number
-
Volume number
80
Issue number
23
First page of article
9058
ISSN of journal
1520-6882
Year of publication
2008
URL
-
Number of additional authors
6
Additional information
Although the introduction of C60+ primary beams has enabled ToF-SIMS to provide a molecular depth profiling and 3D imaging capability, high lateral resolution performance, is severely limited by the pulsed nature of current instruments. A completely new instrument, J105, using a dc primary ion beam that overcomes many of the drawbacks is described. The stream of secondary ions is sampled using a buncher-harmonic-ToF arrangement. The concept is validated by studies of biological samples generating 2D and 3D images showing subcellular molecular localization while maintaining high mass resolution. Two £1m instruments have been installed in the US (2011) and Sweden (2012).
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
