Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Manchester : A - Chemical Engineering
Article title
Direct Analysis of Donor-Acceptor Distance and Relationship to Isotope Effects and the Force Constant for Barrier Compression in Enzymatic H-Tunneling Reactions
Type
D - Journal article
Title of journal
Journal of the American Chemical Society
Article number
-
Volume number
132
Issue number
32
First page of article
11329
ISSN of journal
1520-5126
Year of publication
2010
URL
-
Number of additional authors
4
Additional information
We showed previously (Science, 2006) that hydrogen transfer - an essential component of most biological reactions - is a quantum problem. The significance of this study is in developing a “spectroscopic ruler” to measure small (sub-Angstrom) changes in [hydrogen donor] - [hydrogen acceptor] distances - determining such distances, and their impact on catalytic rate, is crucial to understanding how enzymes break carbon-hydrogen bonds. The work has underpinned subsequent studies by a range of academic-based groups.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
