Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Manchester : A - Chemical Engineering
Article title
A Biomimetic Ferric Hydroperoxo Porphyrin Intermediate
Type
D - Journal article
Title of journal
Angewandte Chemie International Edition
Article number
-
Volume number
49
Issue number
12
First page of article
2099
ISSN of journal
1521-3773
Year of publication
2010
URL
-
Number of additional authors
2
Additional information
One of the big controversies in cytochrome P450 chemistry relates to the nature of the active species, where some studies seem to give evidence of an active iron(III)-hydroperoxo intermediate, while other studies prefer Compound I. This paper highlights the differences in reactivity of Compound I versus iron(III)-hydroperoxo in substrate activation and highlights recent advances in the field. Moreover, it shows that the most likely scenario is a Compound I active species in hydrogen atom abstraction reactions. This is a significant observation and helps with future catalyst design and development.
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
