Output details
15 - General Engineering
University of Edinburgh (joint submission with Heriot-Watt University)
Optimisation of analyte transport in integrated microfluidic affinity sensors for the quantification of low levels of analyte
This paper presents novel microfluidic biosensor designs with high yield as well as uniform spatial attachment of biomarker molecules. While conventional designs achieve either high yield or uniform attachment, these designs enable the fabrication of sensors with enhanced detection at low concentrations from nanolitre samples. The results were applied in the design of the microfluidic biosensor in the £199K BBSRC project (BB/D014476/1). The specialised geometry of these sensors inspired the development of new printing techniques and aligned integration of micron-sized biomolecule patterns in microfluidic biosensors for lab-on-a-chip devices (DoI:10.1016/j.ab.2012.02.020).
