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15 - General Engineering

University of Edinburgh (joint submission with Heriot-Watt University)

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Article title

Raman spectroscopy and CARS microscopy of stem cells and their derivatives

Type

D - Journal article

DOI

10.1002/jrs.2975

Title of journal

Journal of Raman Spectroscopy

Article number

Volume number

Issue number

First page of article

1864

ISSN of journal

0377-0486

Year of publication

2011

URL

http://onlinelibrary.wiley.com/doi/10.1002/jrs.2975/abstract

Number of additional authors

Additional information

The combination of Raman spectroscopy and CARS microscopy was used for the first time to chemically characterise and image stem cells at various stages of differentiation. Changes of relative DNA-RNA cell composition, the separate detection of phosphate and carbonate mineralization of developing bone cells, and the synthesis of lipid droplets in fat cells are reported. The broader importance of this development of cell biochemical ‘fingerprinting’ to stem cell research and regenerative medicine was identified in Trends in Biotechnology (DoI:10.1016/j.tibtech.2013.01.008). This work represents the first output of an MRC Discipline Hopping Award (G0802632).

Interdisciplinary

Yes

Cross-referral requested

Research group

A - Manufacturing & Materials

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract