Output details
15 - General Engineering
University of Kent
Red Blood Cell Thermal Fluctuations: Comparison Between Experiment and Molecular Dynamics Simulations
This work, the result of collaboration with the University of Exeter (Prof. Winlove, C.P.Winlove@exeter.ac.uk ), proposes a new technique to measure mechanical properties of human red blood cells using membrane thermal fluctuation spectra. The new technique is currently used to identify differences between normal and diseased cells and to explain microcirculatory changes in some blood diseases. For example, Clark et al. used the technique to investigate red blood cell elasticity in patients with sepsis
(http://poster-consultation.esicm.org/ModuleConsultationPoster/posterDetail.aspx?intIdPoster=3153), and Hale et al. used the technique to study the effect of hydroperoxides on red blood cell membrane mechanical properties (Biophys. J., 2011, 101, 1921).
