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Oxidative-Nitrosative Stress and Systemic Vascular Function in Highlanders With and Without Exaggerated Hypoxemia

First ever human study as part of an international collaboration led by Bailey to demonstrate that impaired systemic vascular function in chronic mountain sickness patients is due to a free radical-mediated loss of nitric oxide subsequent to vitamin C deficiency. This has set the research agenda by providing an alternative treatment strategy (vitamin C repletion through diet and/or infusion) that will reduce their risk of premature cardiovascular disease. Paper led to invited plenary talks at an international conference (International Conference on Environmental Ergonomics, Queenstown, New Zealand, 2013) and 2013 Cheltenham Science Festival (Will humans evolve in the future?)