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Spectrally resolved bioluminescence tomography using the reciprocity approach

<28>This paper was the first published work, which developed and demonstrated the use of the reciprocity approach for inverse problems within bioluminescence based imaging, which dramatically improves the computational efficiency of multi-spectral Bioluminescence tomography (typically by a factor 1000 in 3D imaging). It builds upon earlier work, which demonstrated the use of multi-wavelength imaging to overcome uniqueness in Bioluminescence tomography. The developed algorithms and open-source software are now widely used within the photonics imaging groups, and the method is adapted within the most popular commercial pre-clinical system (The IVIS Spectrum from Perkin Elmer).