Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Bradford
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Article title
Development of a novel liquid crystal based cell traction force transducer system
Type
D - Journal article
Title of journal
Biosensors and Bioelectronics
Article number
-
Volume number
39
Issue number
1
First page of article
14
ISSN of journal
09565663
Year of publication
2013
URL
-
Number of additional authors
4
Additional information
A novel cholesteryl ester liquid crystal (CELC) based cell traction force transducer system with improved sensitivity, flexibility and linear responses was developed. The LC had Young’s modulus close to that of the epidermis. CELC promoted expressions of punctuated vinculin and short circumferential actin filaments at the perimeter of the cells. The linear viscoelastic surface of the LCs is very sensitive to traction forces of adherent cells and can detect a wide range of cell traction forces (10–120nN) with spatial resolution of ~1mm. The systems presented here have significant potentials for development of novel single cell based pharmacological assays.
Interdisciplinary
-
Cross-referral requested
-
Research group
A - Advanced Materials Engineering
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
