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Decreased brain venous vasculature visibility on susceptibility-weighted imaging venography in patients with multiple sclerosis is related to chronic cerebrospinal venous insufficiency

The work presents a major new finding relating to MS. With >90 subjects, this study was the first clinical trial to demonstrate that MS is associated with physical loss of cerebral veins - subsequently confirmed by Sinnecker et al (Multiple Sclerosis 2013, 19(3):316-325) and Zeng et al (European Radiology 2013, 23(3):869-878). Beggs used a systems engineering approach to interpret the data and demonstrated (for the first time) that vein loss is strongly associated with constricted venous outflow. Subsequently, Beggs (Neurological Research 2012 34(8):793-801) developed a venous diagnostic metric to distinguish between MS patients and healthy controls with 100% accuracy.