Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University of Bradford
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Article title
High resolution imaging of bio-molecular binding studies using a widefield surface plasmon microscope
Type
D - Journal article
Title of journal
Sensors and Actuators B: Chemical
Article number
-
Volume number
129
Issue number
2
First page of article
566
ISSN of journal
09254005
Year of publication
2008
URL
-
Number of additional authors
8
Additional information
This is an original work that presents 'proof of principle' in results. Its significance is that the widefield surface plasmon resonance (WSPR) microscope used here enabled interfacial binding images with significantly higher lateral resolutions than prism based systems. We demonstrated the functionality of the WSPR by imaging a sequence of binding events between micro-patterned ECM proteins and their specific antibodies. Using the WSPR system a change in contrast was observed with each binding event. This work has provided better understanding of protein-surface interactions at the interface.
Interdisciplinary
-
Cross-referral requested
-
Research group
A - Advanced Materials Engineering
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
