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12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering

University College London

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Article title

Scale-up of human embryonic stem cell culture using a hollow fibre bioreactor

Type

D - Journal article

DOI

10.1007/s10529-012-1033-1

Title of journal

Biotechnology Letters

Article number

Volume number

Issue number

First page of article

2307

ISSN of journal

0141-5492

Year of publication

2012

URL

Number of additional authors

Additional information

Cell therapies require the manufacturing of cells in sufficient quantity for routine clinical practice. The current method of growing cells on the surface of a flat-sided bottle is pragmatically acceptable for clinical proof of concept but not for scaled Good Manufacturing Practice (GMP) production. Collaborating with Beckman Coulter (now acquired by Terumo) we were the first to demonstrate that even highly delicate human embryonic stem cells can be successfully grown in a closed system of parallel hollow fibres. Terumo is currently using our data to support development of their next generation GMP hollow fibre bioreactors (Dr Stefano Baila, stefano.baila@terumobct.com).

Interdisciplinary

Cross-referral requested

Research group

None

Proposed double-weighted

Double-weighted statement

Reserve for a double-weighted output

Non-English

English abstract