Output details
12 - Aeronautical, Mechanical, Chemical and Manufacturing Engineering
University College London
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Article title
Shear-Induced Unfolding of Lysozyme Monitored In Situ
Type
D - Journal article
Title of journal
BIOPHYS J
Article number
-
Volume number
96
Issue number
10
First page of article
4231
ISSN of journal
0006-3495
Year of publication
2009
URL
-
Number of additional authors
4
Additional information
The paper reports on a novel study of shear induced protein unfolding in collaboration with the University of Manchester; it was supported by the EPSRC Chemistry –Chemical Engineering Interface Initiative EPSRC (EP/D500818/1, EP/F007736/1) and described as ‘a challenging interdisciplinary venture’ by reviewers. It represents the first successful attempt in UK to monitor flow induced conformational changes of proteins in real time. The work is of significant importance to therapeutic protein production and has lead to further collaborations and funding from the Technology Strategy Board (TP 4783-44 269, Technology Inspired Collaborative R&D).
Interdisciplinary
-
Cross-referral requested
-
Research group
None
Proposed double-weighted
No
Double-weighted statement
-
Reserve for a double-weighted output
No
Non-English
No
English abstract
-
