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Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells.

This study is part of a series investigating the link between energy metabolism and cell function, funded via both an EPSRC Platform grant and a BBSRC grant. This paper focuses on mesenchymal stem cells and is significant in demonstrating for the first time that continuous and uninterrupted regulation of oxygen levels alters initial selection of stem cell sub-populations that have enhanced proliferative and differentiation potential. These findings are being investigated for the development of new processing methods for regenerative therapies. The findings were used to support a successful application for a Marie Curie fellowship for Stephen Thorpe.